Biological and Medical Applications of Materials and Interfaces
- Haoyang Liu
Haoyang Liu
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
The Center of Joint and Sports Medicine, Orthopedics Department, Zhongda Hospital, Southeast University, 210009 Nanjing, China
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- Yue Zhu
Yue Zhu
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
More by Yue Zhu
- Weixu Chen
Weixu Chen
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
Xuzhou Central Hospital Affiliated to Medical School of Southeast University, 221000 Xuzhou, China
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- Renwang Sheng
Renwang Sheng
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
More by Renwang Sheng
- Chuanquan Liu
Chuanquan Liu
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
More by Chuanquan Liu
- Yuzhi Sun
Yuzhi Sun
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, 210008 Nanjing, China
- Jia Liu
Jia Liu
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
More by Jia Liu
- Mingyue Wang
Mingyue Wang
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
More by Mingyue Wang
- Jun Lu*
Jun Lu
The Center of Joint and Sports Medicine, Orthopedics Department, Zhongda Hospital, Southeast University, 210009 Nanjing, China
*Email: [emailprotected]
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- Jialin Chen*
Jialin Chen
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
Department of Ophthalmology, Zhongda Hospital, Southeast University, 210009 Nanjing, China
China Orthopedic Regenerative Medicine Group (CORMed), 310058 Hangzhou, China
*Email: [emailprotected]
More by Jialin Chen
- Wei Zhang*
Wei Zhang
School of Medicine, and Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 210009 Nanjing, China
China Orthopedic Regenerative Medicine Group (CORMed), 310058 Hangzhou, China
*Email: [emailprotected]
More by Wei Zhang
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
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https://pubs.acs.org/doi/10.1021/acsami.5c01731
Published April 17, 2025
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The advancement of nanomedicine requires a thorough understanding of the intrinsic bioactivity and molecular interactions of nanomaterials for safe and effective clinical applications, which remains lacking for most currently developed nanomaterials. Here, we uncover the unique intrinsic bioactivity and regulatory mechanisms of carbon-based fullerol nanomaterials through high-throughput molecular analysis and explore their therapeutic potential for tissue regeneration using tissue engineering approaches. Fullerol exhibits intrinsic pro-differentiation and antioxidant properties that enhance the osteogenesis and chondrogenesis of MSCs. Mechanistically, proteomic analysis combined with small-molecule inhibition studies reveals that fullerol is internalized by MSCs via clathrin-mediated endocytosis and activates NRF2 signaling, thereby exerting antioxidant effects that restore impaired MSC viability and differentiation under oxidative stress. Leveraging these unique bioactivities, we develop a fullerol-functionalized hydrogel with feasible physicochemical properties and triple biological functions in antioxidant, pro-osteogenic, and pro-chondrogenic effects and confirm its great regenerative capacity for both cartilage and subchondral bone by promoting structural restoration and improving functional recovery in a rat osteochondral defect model. Our findings offer new insights into the intricate interactions between stem cells and nanomaterials at the cellular and molecular levels and broaden the potential biomedical applications of fullerol for future cartilage and bone regeneration therapies.
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© 2025 American Chemical Society
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- Cells
- Differentiation
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- Oxidative stress
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 17, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
Request reuse permissions
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